Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat

Eddie Wei; Horace Loh; E. Leong Way

doi:10.1016/0014-2999(76)90276-4

Potency of the N^3im-methyl analog of TRH in the induction of shaking movements in the rat

Eddie Wei
, Horace Loh
, E. Leong Way

Pharmacology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N^3im-methyl TRH was approximately 10X more potent than TRH, wherease N^1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

Original language	English (US)
Pages (from-to)	227-229
Number of pages	3
Journal	European Journal of Pharmacology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(76)90276-4
State	Published - Mar 1976

Keywords

N-and N-methyl TRH
Shaking in rats
Thyrotropin-releasing hormone (TRH)

Publisher link

10.1016/0014-2999(76)90276-4

Find It

Find It at U of M Libraries

Cite this

@article{e8041ea8086749ebbb96c88db1aac965,

title = "Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat",

abstract = "The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.",

keywords = "N-and N-methyl TRH, Shaking in rats, Thyrotropin-releasing hormone (TRH)",

author = "Eddie Wei and Horace Loh and Way, \{E. Leong\}",

year = "1976",

month = mar,

doi = "10.1016/0014-2999(76)90276-4",

language = "English (US)",

volume = "36",

pages = "227--229",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat

AU - Wei, Eddie

AU - Loh, Horace

AU - Way, E. Leong

PY - 1976/3

Y1 - 1976/3

N2 - The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

AB - The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

KW - N-and N-methyl TRH

KW - Shaking in rats

KW - Thyrotropin-releasing hormone (TRH)

UR - https://www.scopus.com/pages/publications/0017104634

UR - https://www.scopus.com/pages/publications/0017104634#tab=citedBy

U2 - 10.1016/0014-2999(76)90276-4

DO - 10.1016/0014-2999(76)90276-4

M3 - Article

C2 - 816658

AN - SCOPUS:0017104634

SN - 0014-2999

VL - 36

SP - 227

EP - 229

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -