Posttraumatic Cerebral Hemispheric Disconnection Syndrome

Alan B. Rubens, Norman Geschwind, Mark Mahowald, Angeline Mastri

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Gross and microscopic lesions of the corpus callosum and neighboring structures are common in severe closed head injury. This report is the first, to our knowledge, to confirm neuropathologically the occurrence of extensive traumatic destruction of the corpus callosum in a patient with left-sided apraxia and agraphia. It also demonstrates that large traumatic lesions of the corpus callosum may occur without prolonged posttraumatic coma, vegetative state, or death. In our patient, coexisting extracallosal hemispheric lesions may have modified the effects of callosal pathology. Cases of this type may be more common than generally appreciated, but since symptoms of hemispheric disconnection are not apparent in ordinary behavior, specific tests of callosal function must be employed if disconnection phenomena are to be detected in the posttraumatic period.

Original languageEnglish (US)
Pages (from-to)750-755
Number of pages6
JournalArchives of Neurology
Issue number12
StatePublished - Dec 1977

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Copyright 2015 Elsevier B.V., All rights reserved.


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