TY - JOUR
T1 - Posttraumatic Cerebral Hemispheric Disconnection Syndrome
AU - Rubens, Alan B.
AU - Geschwind, Norman
AU - Mahowald, Mark
AU - Mastri, Angeline
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1977/12
Y1 - 1977/12
N2 - Gross and microscopic lesions of the corpus callosum and neighboring structures are common in severe closed head injury. This report is the first, to our knowledge, to confirm neuropathologically the occurrence of extensive traumatic destruction of the corpus callosum in a patient with left-sided apraxia and agraphia. It also demonstrates that large traumatic lesions of the corpus callosum may occur without prolonged posttraumatic coma, vegetative state, or death. In our patient, coexisting extracallosal hemispheric lesions may have modified the effects of callosal pathology. Cases of this type may be more common than generally appreciated, but since symptoms of hemispheric disconnection are not apparent in ordinary behavior, specific tests of callosal function must be employed if disconnection phenomena are to be detected in the posttraumatic period.
AB - Gross and microscopic lesions of the corpus callosum and neighboring structures are common in severe closed head injury. This report is the first, to our knowledge, to confirm neuropathologically the occurrence of extensive traumatic destruction of the corpus callosum in a patient with left-sided apraxia and agraphia. It also demonstrates that large traumatic lesions of the corpus callosum may occur without prolonged posttraumatic coma, vegetative state, or death. In our patient, coexisting extracallosal hemispheric lesions may have modified the effects of callosal pathology. Cases of this type may be more common than generally appreciated, but since symptoms of hemispheric disconnection are not apparent in ordinary behavior, specific tests of callosal function must be employed if disconnection phenomena are to be detected in the posttraumatic period.
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U2 - 10.1001/archneur.1977.00500240038006
DO - 10.1001/archneur.1977.00500240038006
M3 - Article
C2 - 588095
AN - SCOPUS:0017609802
VL - 34
SP - 750
EP - 755
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 12
ER -