Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The transcription factor Krüppel-like factor 2 (KLF2) controls the emigration of conventional T cells from the thymus through its regulation of the cell surface receptor S1P1. Prior to KLF2 expression, developing T cells require a positive selection signal through the TCR. However, following positive selection there are time, spatial, and maturational events that occur before KLF2 is finally upregulated and emigration occurs. We are interested in determining the signals that upregulate KLF2 and allow thymocytes to emigrate into circulation and whether they are linked to functional maturation. In endothelial cells KLF2 expression has been shown to be dependent on the mitogen-activated protein kinase ERK5. Furthermore, it has been reported that IL-7 signaling leads to the phosphorylation of ERK5. Thus, we hypothesized that IL-7R signaling through ERK5 could drive the expression of KLF2. In this study, we provide evidence that this hypothesis is incorrect. We also found that CD8 lineage specification occurred normally in the absence of IL-7R signaling, in contrast to a recently proposed model. We showed that both CD4 and CD8 T cells complete maturation and express KLF2 independently of ERK5 and IL-7.

Original languageEnglish (US)
Pages (from-to)1343-1347
Number of pages5
JournalJournal of Immunology
Issue number3
StatePublished - Feb 1 2011


Dive into the research topics of 'Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5'. Together they form a unique fingerprint.

Cite this