Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations

Pablo Perez-Martinez, Nikos Yiannakouris, Jose Lopez-Miranda, Donna Arnett, Michael Tsai, Enrique Galan, Robert Straka, Javier Delgado-Lista, Michael Province, Juan Ruano, Ingrid Borecki, James Hixson, Bibiana Garcia-Bailo, Francisco Perez-Jimenez, Jose M. Ordovas

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27 Scopus citations

Abstract

Background: Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome. Objective: We aimed to examine whether the presence of polymorphisms at the perilipin (PLIN) locus (PLIN1, 6209T→C; PLIN4, 11482G→A; PLIN5, 13041A→G; and PLIN6, 14995A→T) influence postprandial lipoprotein metabolism in 2 white populations. Design: Eighty-eight healthy Spanish men and 271 healthy US subjects (men and women) underwent an oral-fat-load test in 2 independent studies. Blood samples were taken in the fasting state and during the postprandial phase at regular intervals. Total cholesterol and triacylglycerol and triacylglycerol in triacylglycerol-rich lipoproteins (TRL, large and small) were measured. Results: Carriers of the minor C allele at the PLIN1 variant displayed lower postprandial concentrations of large-TRL triacylglycerol (Spanish subjects: P = 0.024; US subjects: P = 0.005) than did subjects carrying the T/T genotype. The same pattern was observed in the Spanish population at the PLIN4 locus (P = 0.015), and both SNPs were in strong linkage disequilibrium. In both populations, subjects carrying the minor C and A alleles at PLIN1 and PLIN4, respectively, had significantly lower postprandial concentrations of plasma triacylglycerol (P < 0.05) and lower concentrations of small-TRL triacylglycerol than did those who were homozygous for the major alleles at PLIN1 and PLIN4 (Spanish subjects: P = 0.020 and 0.008, respectively; US subjects: P = 0.021 and 0.035, respectively). Conclusion: These 2 studies suggest that the presence of the minor C and A alleles at PLIN1 and PLIN4, respectively, are associated with a lower postprandial response that may result in lower atherogenic risk for these persons.

Original languageEnglish (US)
Pages (from-to)744-752
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Nutrigenetics
  • Perilipin
  • Postprandial lipemia
  • Single-nucleotide polymorphisms
  • Triacylglycerol-rich lipoproteins

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    Perez-Martinez, P., Yiannakouris, N., Lopez-Miranda, J., Arnett, D., Tsai, M., Galan, E., Straka, R., Delgado-Lista, J., Province, M., Ruano, J., Borecki, I., Hixson, J., Garcia-Bailo, B., Perez-Jimenez, F., & Ordovas, J. M. (2008). Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations. American Journal of Clinical Nutrition, 87(3), 744-752. https://doi.org/10.1093/ajcn/87.3.744