Abstract
Introduction Pancreaticoduodenectomy (PD) performed for pancreatic ductal adenocarcinoma (PDA) has a postoperative morbidity of 40-50%. In this study, we analyzed the impact of high grade complications after PD for PDA on overall survival. Methods A total of 596 patients that underwent PD for PDA between 2001 and 2009 were identified from a prospective database. Complications were defined and graded (1-5) as per our Institutional Surgical Secondary Events Program. High grade complications were defined as ≥grade 3. Postoperative mortality (≤90 days) was excluded. Univariate and multivariate analyses were performed to identify factors associated with overall survival. Results Median survival was 24 months. Overall complication rate was 51% (301/596). Low grade complications were recorded in 266 patients (45%) and high grade complications in 22% (n = 129). Our 90 day mortality was 3.7% (n = 22). Anastomotic fistula/leak/abscess rate was 14% (n = 82). Multivariate Cox-Regression analysis identified node positivity, estimated blood loss (EBL) >600 ml, length of stay (LOS) >10 days, margin positivity, and vascular procedures as predictors of decreased overall survival (P < 0.05). High grade complications were not associated with overall survival (P = 0.948). Conclusion In this study, the occurrence of high grade postoperative complications was not associated with overall survival.
Original language | English (US) |
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Pages (from-to) | 188-193 |
Number of pages | 6 |
Journal | Journal of Surgical Oncology |
Volume | 113 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Wiley Periodicals, Inc.
Keywords
- complications
- pancreatic ductal adenocarcinoma
- pancreaticoduodenectomy
- survival