Postextraction ridge preservation by using dense PTFE membranes: A systematic review and meta-analysis

Georgios Chatzopoulos, Vasiliki Koidou, Michelle Sonnenberger, Deborah K Johnson, Haitao Chu, Larry F. Wolff

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


STATEMENT OF PROBLEM: The use of dense polytetrafluoroethylene (dPTFE) membranes in alveolar ridge preservation may help reduce the risk of bacterial contamination and infection, maintaining the soft-tissue anatomy. However, systematic reviews on their efficacy in postextraction sites are lacking.

PURPOSE: The purpose of this systematic review and meta-analysis was to assess the efficacy of alveolar ridge preservation with dPTFE membranes when used alone or in combination with bone grafting materials in postextraction sites.

MATERIAL AND METHODS: An electronic search up to February 2021 was conducted by using PubMed, Embase, and the Cochrane library to detect studies using dPTFE membranes in postextraction sites. An additional manual search was performed in relevant journals. Clinical and radiographic dimensional changes of the alveolar ridge, histomorphometric, microcomputed tomography, implant-related findings, and rate of complications were recorded. One-dimensional meta-analysis was performed to calculate the overall means and 95% confidence intervals (α=.05).

RESULTS: A total of 23 studies, 14 randomized controlled trials, 4 retrospective cohort studies, 3 case series, and 2 prospective nonrandomized clinical trials, met the inclusion criteria. Five studies were included in the quantitative analysis. The meta-analysis revealed that the use of dPTFE membranes resulted in a statistically significant (P=.042) increase in clinical keratinized tissue of 3.49 mm (95% confidence interval [CI]: 0.16, 6.83) when compared with extraction alone. Metaregression showed that the difference of 1.10 mm (95% CI: -0.14, 2.35) in the radiographic horizontal measurements was not significant (P=.082), but the difference of 1.06 mm (95% CI: 0.51, 1.62) in the radiographic vertical dimensional change between dPTFE membranes+allograft and extraction alone was statistically significant (P<.001).

CONCLUSIONS: The use of dPTFE membranes was better than extraction alone in terms of keratinized tissue width and radiographic vertical bone loss.

Original languageEnglish (US)
Pages (from-to)410-419
Number of pages10
JournalJournal of Prosthetic Dentistry
Issue number3
StatePublished - Mar 2024

Bibliographical note

Funding Information:
Funding: Supported in part through the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program, grant UL1TR002494 .

Publisher Copyright:
© 2022 Editorial Council for The Journal of Prosthetic Dentistry

PubMed: MeSH publication types

  • Meta-Analysis
  • Systematic Review
  • Journal Article
  • Review


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