Posterior Hypothalamic Effect on Gastrointestinal Blood Flow in the Conscious Cat

Robert B. Gilsdorf, Louis F. Urdaneta, Arnold S. Leonard, John P. Delaney

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cats receiving PHS were found to have significantly less blood flow to the colon mucosa (51%), submucosa (60%), and muscularis (57%) and to small intestinal mucosa (70%) than control cats. No significant differences were detected in the blood flow to the tissues of the esophagus, stomach, gallbladder, or pancreas. Despite significant increases in blood pressure (147% of control) and pulse (127% of control) cardiac output was not different in the two groups. Tissue blood flows in the control group ranged from the high in the pancreas of 1.36 ± 0.15 ml/g/min followed by the colon, duodenum, jejunum, ileum, and gastric corpus to the low in the gastric antrum of 0.54 ± 0.04 ml/g/min. It is concluded that posterior hypothalamic stimulation can affect tissue blood flow in the gastrointestinal organs but the magnitude of the changes is not sufficient to provide the sole explanation for reported physiologic and pathologic changes associated with such stimuli.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Jun 1973

Bibliographical note

Funding Information:
Supported by a grant from the John A. Hartford Foundation.


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