Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps still exist in our knowledge regarding the role of p53 post-translational modifications in carcinogenesis and cancer prevention. A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53.
Bibliographical noteFunding Information:
The plethora of literature related to the response of p53 to stress makes a complete and extensive review extremely challenging and we apologize in advance for any inadvertent omission. This work is supported by the Hormel Foundation, grants from the National Institutes of Health and a grant from the American Institute for Cancer Research.