Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

Aaron C. Goldstrohm, Traci M.Tanaka Hall, Katherine M. McKenney

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory networks, biological functions, and relevance to diseases. Pumilio proteins bind an extensive network of mRNAs and repress protein expression by inhibiting translation and promoting mRNA decay. Opposingly, in certain contexts, they can activate protein expression. Pumilio proteins also regulate noncoding (nc)RNAs. The ncRNA, ncRNA activated by DNA damage (NORAD), can in turn modulate Pumilio activity. Genetic analysis provides new insights into Pumilio protein function. They are essential for growth and development. They control diverse processes, including stem cell fate, and neurological functions, such as behavior and memory formation. Novel findings show that their dysfunction contributes to neurodegeneration, epilepsy, movement disorders, intellectual disability, infertility, and cancer.

Original languageEnglish (US)
Pages (from-to)972-990
Number of pages19
JournalTrends in Genetics
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

Proteins
Untranslated RNA
RNA-Binding Proteins
RNA Stability
Movement Disorders
Growth and Development
Intellectual Disability
Infertility
DNA Damage
Epilepsy
Stem Cells
Messenger RNA
Neoplasms

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

Cite this

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. / Goldstrohm, Aaron C.; Hall, Traci M.Tanaka; McKenney, Katherine M.

In: Trends in Genetics, Vol. 34, No. 12, 01.12.2018, p. 972-990.

Research output: Contribution to journalReview article

Goldstrohm, Aaron C. ; Hall, Traci M.Tanaka ; McKenney, Katherine M. / Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. In: Trends in Genetics. 2018 ; Vol. 34, No. 12. pp. 972-990.
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