Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

Keyphrases

• High-throughput Screening 100%
• Disubstituted 100%
• Structural Alerts 100%
• Pyrrol-2-ones 100%
• Chemotype 75%
• Histone Acetylation 50%
• Nogo-A 50%
• Rtt109 50%
• Cell-free 25%
• Biological Targets 25%
• Drug Discovery 25%
• Drug Development 25%
• Small Molecule Inhibitors 25%
• Corporate 25%
• Chemical Probes 25%
• Triage 25%
• Decision-making Process 25%
• Structural Analogues 25%
• Physicochemical Properties 25%
• β-lactamase 25%
• Structure-activity Relationship 25%
• Histone Acetyltransferase 25%
• Activity-based Probes 25%
• Early Drug Discovery 25%
• Screen Yield 25%
• La Protein 25%
• Risk Mitigation Strategies 25%
• Frequent Hitter 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Discovery 100%
• Histone 100%
• Drug Development 50%
• Structure Activity Relationship 50%
• Penicillinase 50%
• Biological Target 50%
• La Antigen 50%
• Histone Acetyltransferase 50%

Chemistry

• NMR Spectroscopy 100%
• Histone 100%
• Drug Discovery 66%
• Acetylation 66%
• Chemical Substance Type 33%
• Structure-Activity Relationship 33%