Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition

Jukuan Zheng, Kaiyi Liu, Darrell H. Reneker, Matthew L. Becker

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-l-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.

Original languageEnglish (US)
Pages (from-to)17274-17277
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number41
DOIs
StatePublished - Oct 17 2012

Fingerprint Dive into the research topics of 'Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition'. Together they form a unique fingerprint.

Cite this