Possible Role of Snail Expression as a Prognostic Factor in Canine Mammary Neoplasia

K. S. Im, J. H. Kim, N. H. Kim, C. H. Yu, T. Y. Hur, J. H. Sur

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Epithelial cells adhere tightly to each other by cell-to-cell adhesion and through the basement membrane barrier to prohibit movement. In carcinomas, neoplastic epithelial cells lose their epithelial characteristics and acquire a mesenchymal phenotype during the epithelial-mesenchymal transition (EMT) for invasion and metastasis. The aim of this study was to identify Snail expression and examine the role of Snail protein in canine mammary tumour progression. Immunohistochemical expression of Snail, E-cadherin, oestrogen receptor, human epidermal growth factor receptor-2, cytokeratin 14 and p63 was analyzed in 54 samples of canine mammary epithelial tumours (11 adenomas and 43 carcinomas). Expression of mRNA encoding Snail was evaluated in seven samples (one normal mammary gland, two adenomas and four carcinomas) by reverse transcriptase-polymerase chain reaction. Snail mRNA was detected in all samples. Snail expression correlated significantly with histological type, grade and lymphatic invasion. However, there was no association between Snail expression and molecular subtype and between Snail expression and that of E-cadherin. Snail, a hallmark of EMT, might play an important role in invasion and metastasis of canine mammary carcinomas.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalJournal of Comparative Pathology
Issue number2-3
StatePublished - Aug 2012

Bibliographical note

Funding Information:
None of the authors has any financial or personal relationship that could inappropriately influence or bias the content of the paper. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2011-0021337 ).

Copyright 2013 Elsevier B.V., All rights reserved.


  • Dog
  • Epithelial-mesenchymal transition
  • Mammary carcinoma
  • Snail

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