Possible effects of the synthetic amino acid, L-ethionine, on memory in rats

Robert L. Lloyd, Donald J. Lewis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Two experiments to explore the behavioral effects of injections of the synthetic amino acid L-ethionine indicated that this drug interferes with the performance of a learned passive avoidance response. Additionally, this deficit was found to occur in the absence of detectable changes in gross motor activity. Because this effect was found when the drug was injected near the time of training, but not when it was injected before testing, and because the effect was found to persist after the drug is believed to have been eliminated from the blood stream, the data were interpreted as reflecting a possible effect upon some aspect of memory functioning.

Original languageEnglish (US)
Pages (from-to)1015-1019
Number of pages5
JournalPhysiology and Behavior
Volume22
Issue number5
DOIs
StatePublished - May 1979

Bibliographical note

Funding Information:
1This research was supported by Research Grant BMS 74-19492 from the National Science Foundation, D. J. Lewis, Principal Investigator. ~Thesis submitted in partial fulfillment of the requirements for the degree of Master of Arts.

Keywords

  • Amnesia
  • Drugs
  • Learning
  • Memory

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