Possible associations between successful aging and polymorphic markers in the werner gene region

Mari Sild; Cemile Koca; Mette H. Bendixen; Henrik Frederiksen; Matt McGue; Steen Kølvraa; Kaare Christensen; Bjørn Nexø

doi:10.1196/annals.1354.041

Possible associations between successful aging and polymorphic markers in the werner gene region

Mari Sild, Cemile Koca, Mette H. Bendixen, Henrik Frederiksen, Matt McGue, Steen Kølvraa, Kaare Christensen, Bjørn Nexø

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.

Original language	English (US)
Pages (from-to)	309-310
Number of pages	2
Journal	Annals of the New York Academy of Sciences
Volume	1067
Issue number	1
DOIs	https://doi.org/10.1196/annals.1354.041
State	Published - May 2006
Externally published	Yes

Keywords

Cognition
Normal aging
Werner syndrome
WRN

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10.1196/annals.1354.041

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abstract = "Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.",

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year = "2006",

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doi = "10.1196/annals.1354.041",

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T1 - Possible associations between successful aging and polymorphic markers in the werner gene region

AU - Sild, Mari

AU - Koca, Cemile

AU - Bendixen, Mette H.

AU - Frederiksen, Henrik

AU - McGue, Matt

AU - Kølvraa, Steen

AU - Christensen, Kaare

AU - Nexø, Bjørn

PY - 2006/5

Y1 - 2006/5

N2 - Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.

AB - Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.

KW - Cognition

KW - Normal aging

KW - Werner syndrome

KW - WRN

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Possible associations between successful aging and polymorphic markers in the werner gene region

Abstract

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