Possible associations between successful aging and polymorphic markers in the werner gene region

Mari Sild, Cemile Koca, Mette H. Bendixen, Henrik Frederiksen, Matt McGue, Steen Kølvraa, Kaare Christensen, Bjørn Nexø

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5′ flanking region and 5′ UTR to be significantly associated with the cognitive functioning level in old age.

Original languageEnglish (US)
Pages (from-to)309-310
Number of pages2
JournalAnnals of the New York Academy of Sciences
Volume1067
Issue number1
DOIs
StatePublished - May 2006

Keywords

  • Cognition
  • Normal aging
  • WRN
  • Werner syndrome

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