Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers

Danielle Compton; Fabienne Wavrant DeVriéze; Ronald C. Petersen; Eric Tangalos; Ling Li; John Hardy

doi:10.1016/S0304-3940(02)00703-6

Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers

Danielle Compton, Fabienne Wavrant DeVriéze, Ronald C. Petersen, Eric Tangalos, Ling Li, John Hardy

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.

Original language	English (US)
Pages (from-to)	60-62
Number of pages	3
Journal	Neuroscience Letters
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00703-6
State	Published - Oct 4 2002

Bibliographical note

Funding Information:
Supported by the NIA/NIH Mayo Clinic Alzheimer Center.

Keywords

Alzheimer's disease
Apolipoprotein(a)
Apolipoprotein(a) locus
Cholesterol
Lipoprotein(a)
Polymorphisms

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10.1016/S0304-3940(02)00703-6

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title = "Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers",

abstract = "Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.",

keywords = "Alzheimer's disease, Apolipoprotein(a), Apolipoprotein(a) locus, Cholesterol, Lipoprotein(a), Polymorphisms",

author = "Danielle Compton and {Wavrant DeVri{\'e}ze}, Fabienne and Petersen, {Ronald C.} and Eric Tangalos and Ling Li and John Hardy",

note = "Funding Information: Supported by the NIA/NIH Mayo Clinic Alzheimer Center.",

year = "2002",

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doi = "10.1016/S0304-3940(02)00703-6",

language = "English (US)",

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T1 - Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers

AU - Compton, Danielle

AU - Wavrant DeVriéze, Fabienne

AU - Petersen, Ronald C.

AU - Tangalos, Eric

AU - Li, Ling

AU - Hardy, John

N1 - Funding Information: Supported by the NIA/NIH Mayo Clinic Alzheimer Center.

PY - 2002/10/4

Y1 - 2002/10/4

N2 - Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.

AB - Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.

KW - Alzheimer's disease

KW - Apolipoprotein(a)

KW - Apolipoprotein(a) locus

KW - Cholesterol

KW - Lipoprotein(a)

KW - Polymorphisms

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U2 - 10.1016/S0304-3940(02)00703-6

DO - 10.1016/S0304-3940(02)00703-6

M3 - Article

C2 - 12359323

AN - SCOPUS:0037020491

SN - 0304-3940

VL - 331

SP - 60

EP - 62

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers

Abstract

Bibliographical note

Keywords

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