TY - JOUR
T1 - Positron emission tomography and leiomyomas
T2 - Clinicopathologic analysis of 3 cases of PET scan-positive leiomyomas and literature review
AU - Chura, Justin C.
AU - Truskinovsky, Alexander M.
AU - Judson, Patricia L.
AU - Johnson, Linda
AU - Geller, Melissa A
AU - Downs, Levi S
PY - 2007/1
Y1 - 2007/1
N2 - Introduction: Studies have suggested that PET scans can differentiate between leiomyomas and leiomyosarcomas. Our experience, however, shows that PET scan-positive smooth muscle tumors are not necessarily malignant. Case reports: Three patients with cancer underwent PET imaging. In all three, the most worrisome finding was a PET scan-positive uterine tumor. After surgical extirpation, all three uterine tumors were found to be benign smooth muscle neoplasms. Discussion: To explore the potential reason these tumors were positive on PET imaging, we performed a detailed histopathologic and immunohistochemical study of all specimens. Pathologic evaluation revealed a leiomyoma, a cellular leiomyoma, and a stromomyoma. There was no association between an increased Ki67 (proliferative) index and positivity on PET imaging. Increased vascularity, however, appeared to be a feature common to the leiomyomas that were PET-positive.
AB - Introduction: Studies have suggested that PET scans can differentiate between leiomyomas and leiomyosarcomas. Our experience, however, shows that PET scan-positive smooth muscle tumors are not necessarily malignant. Case reports: Three patients with cancer underwent PET imaging. In all three, the most worrisome finding was a PET scan-positive uterine tumor. After surgical extirpation, all three uterine tumors were found to be benign smooth muscle neoplasms. Discussion: To explore the potential reason these tumors were positive on PET imaging, we performed a detailed histopathologic and immunohistochemical study of all specimens. Pathologic evaluation revealed a leiomyoma, a cellular leiomyoma, and a stromomyoma. There was no association between an increased Ki67 (proliferative) index and positivity on PET imaging. Increased vascularity, however, appeared to be a feature common to the leiomyomas that were PET-positive.
KW - Cellular leiomyoma
KW - Leiomyoma
KW - Leiomyosarcoma
KW - Positron emission tomography
KW - Stromomyoma
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U2 - 10.1016/j.ygyno.2006.09.024
DO - 10.1016/j.ygyno.2006.09.024
M3 - Article
C2 - 17126891
AN - SCOPUS:33846124262
SN - 0090-8258
VL - 104
SP - 247
EP - 252
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -
