Abstract
Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241-243 |
| Number of pages | 3 |
| Journal | Journal of Physiology Paris |
| Volume | 92 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1998 |
Bibliographical note
Funding Information:Our work was supported by the Grant Agencies of the Czech Republic and of the Academy of Sciences of the Czech Republic, and by Fogarty International Research Collaboration Award.
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