Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors

Stanislav Tuček, Jan Jakubík, Vladimir Doležal, Esam E. El-Fakahany

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalJournal of Physiology Paris
Volume92
Issue number3-4
DOIs
StatePublished - 1998

Bibliographical note

Funding Information:
Our work was supported by the Grant Agencies of the Czech Republic and of the Academy of Sciences of the Czech Republic, and by Fogarty International Research Collaboration Award.

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