TY - JOUR
T1 - Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors
AU - Tuček, Stanislav
AU - Jakubík, Jan
AU - Doležal, Vladimir
AU - El-Fakahany, Esam E.
N1 - Funding Information:
Our work was supported by the Grant Agencies of the Czech Republic and of the Academy of Sciences of the Czech Republic, and by Fogarty International Research Collaboration Award.
PY - 1998
Y1 - 1998
N2 - Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins.
AB - Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the allosterically induced conformational change also affects the interaction between the receptors and the G proteins.
UR - http://www.scopus.com/inward/record.url?scp=0032105399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032105399&partnerID=8YFLogxK
U2 - 10.1016/S0928-4257(98)80026-0
DO - 10.1016/S0928-4257(98)80026-0
M3 - Article
C2 - 9789816
AN - SCOPUS:0032105399
VL - 92
SP - 241
EP - 243
JO - Journal de Physiologie
JF - Journal de Physiologie
SN - 0928-4257
IS - 3-4
ER -