TY - JOUR
T1 - Posaconazole is effective as salvage therapy in zygomycosis
T2 - a retrospective summary of 91 cases.
AU - van Burik, Jo Anne H.
AU - Hare, Roberta S.
AU - Solomon, Howard F.
AU - Corrado, Michael L.
AU - Kontoyiannis, Dimitrios P.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which therapeutic options are limited, we conducted a retrospective study including 91 patients with zygomycosis (proven zygomycosis, 69 patients; probable zygomycosis, 22 patients). Patients had infection that was refractory to prior antifungal treatment (n=81) or were intolerant of such treatment (n=10) and participated in the compassionate-use posaconazole (800 mg/day) program. The rate of success (i.e., either complete or partial response) at 12 weeks after treatment initiation was 60%, and 21% of patients had stable disease. The overall high success and survival rates reported here provide encouraging data regarding posaconazole as an alternative therapy for zygomycosis.
AB - To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which therapeutic options are limited, we conducted a retrospective study including 91 patients with zygomycosis (proven zygomycosis, 69 patients; probable zygomycosis, 22 patients). Patients had infection that was refractory to prior antifungal treatment (n=81) or were intolerant of such treatment (n=10) and participated in the compassionate-use posaconazole (800 mg/day) program. The rate of success (i.e., either complete or partial response) at 12 weeks after treatment initiation was 60%, and 21% of patients had stable disease. The overall high success and survival rates reported here provide encouraging data regarding posaconazole as an alternative therapy for zygomycosis.
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U2 - 10.1086/500212
DO - 10.1086/500212
M3 - Article
C2 - 16511748
AN - SCOPUS:33744463904
SN - 1058-4838
VL - 42
SP - e61-65
JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
IS - 7
ER -