Portable GMR Handheld Platform for the Detection of Influenza A Virus

Kai Wu, Todd Klein, Venkatramana D. Krishna, Diqing Su, Andres M. Perez, Jian Ping Wang

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Influenza A virus (IAV) is a common respiratory pathogen infecting many hosts including humans, pigs (swine influenza virus or SIV), and birds (avian influenza virus or AIV). Monitoring swine and avian influenza viruses in the wild, farms, and live poultry markets is of great significance for human and veterinary public health. A portable, sensitive, and quantitative immunoassay device will be of high demand especially in the rural and resource-limited areas. We report herein our Z-Lab point-of-care (POC) device for sensitive and specific detection of swine influenza viruses with minimum sample handling and laboratory skill requirements. In the present study, a portable and quantitative immunoassay platform based on giant magnetoresistive (GMR) technology is used for the detection of IAV nucleoprotein (NP) and purified H3N2v. Z-Lab displays quantitative results in less than 10 min with sensitivities down to 15 ng/mL and 125 TCID50/mL for IAV nucleoprotein and purified H3N2v, respectively. This platform allows lab-testing to be performed outdoors and opens up the applications of immunoassays in nonclinical settings.

Original languageEnglish (US)
Pages (from-to)1594-1601
Number of pages8
JournalACS Sensors
Volume2
Issue number11
DOIs
StatePublished - Nov 22 2017

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

Keywords

  • Influenza A virus
  • giant magnetoresistive
  • nonclinical
  • point-of-care device
  • quantitative immunoassay platform

Fingerprint

Dive into the research topics of 'Portable GMR Handheld Platform for the Detection of Influenza A Virus'. Together they form a unique fingerprint.

Cite this