Porous systems

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Porous systems play a significant role in controlled release. Porous membranes and matrices can be used to store drug prior to release, and pore structure plays a significant role in determining release kinetic profiles. In this chapter we review methods used to measure pore structure and mathematical models used to relate pore structure to drug transport properties. Steric and hydrodynamic interactions between drug and pore walls, pore tortuosity, and variation in pore width are identified as factors affecting transport. Percolation theory, which addresses connectedness of random pore networks and its effect on overall releasability of drug and release rate, is discussed. Concepts developed for porous systems can be applied, with some modifications, to transport in other heterogeneous systems, such as tissue interstitium and hydrogels.

Original languageEnglish (US)
Title of host publicationFundamentals and Applications of Controlled Release Drug Delivery
PublisherSpringer US
Pages229-251
Number of pages23
ISBN (Electronic)9781461408819
ISBN (Print)9781461408802
DOIs
StatePublished - Jan 1 2012

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