Porcine reproductive and respiratory syndrome viruses (porcine arteriviruses)

Jeffrey J. Zimmerman, Scott A. Dee, Derald J. Holtkamp, Michael P Murtaugh, Tomasz Stadejek, Gregory W. Stevenson, Montserrat Torremorell, Hanchun Yang, Jianqiang Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Scopus citations


Control of porcine reproductive and respiratory syndrome virus (PRRSV) remains problematic, and economic studies have uniformly shown that PRRSV inflicts major losses on swine health and productivity. A fuller picture of PRRSV genetic relationships and evolutionary origins may be facilitated by whole genome analyses and comparisons of multiple protein coding regions, including the polymerase gene, which is widely used in RNA viral evolutionary analyses. PRRSV viral infection can be divided into three distinct stages: acute infection, persistence, and extinction. Acute infection follows exposure and is characterized by rapid spread to primary sites of replication in lung and lymphoid tissues. PRRSV markedly alters innate immunity and inflammatory and immunoregulatory cytokines in a strain- specific manner. Infection with PRRSV induces immunity that eventually controls the initial infection, eliminates the virus, and establishes memory that is variably protective against future infection.

Original languageEnglish (US)
Title of host publicationDiseases of Swine
Number of pages24
ISBN (Electronic)9781119350927
ISBN (Print)9781119350859
StatePublished - Mar 29 2019

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons, Inc.


  • Economic studies
  • Genome analyses
  • Innate immunity
  • Porcine reproductive and respiratory syndrome virus
  • Swine health
  • Swine productivity


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