Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation

Keyphrases

• Pediatric Subjects 100%
• Population Pharmacokinetics 100%
• Hematopoietic Cell Transplantation 100%
• Clofarabine 100%
• Pretransplant 100%
• Pharmacokinetics 16%
• Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) 16%
• Malignant Disorders 16%
• Pediatric 8%
• Monotherapy 8%
• Renal Function 8%
• Plasma Samples 8%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 8%
• Fludarabine 8%
• Preparative Regimen 8%
• Patient Characteristics 8%
• Early Adulthood 8%
• First-order 8%
• NONMEM 8%
• Pharmacokinetic Model 8%
• One-child 8%
• 1-year-olds 8%
• Parameter Estimation 8%
• Nucleosides 8%
• Final Model 8%
• Residual Error 8%
• Clinical Parameters 8%
• Population Pharmacokinetic Model 8%
• Central Compartment 8%
• Drug Disposition 8%
• Dosing Strategy 8%
• Nucleoside Analogues 8%
• Pharmacokinetic Evaluation 8%
• Individualized Dosing 8%
• Renal Elimination 8%
• Drug Adverse Events 8%
• Covariate Modelling 8%
• Actual Weight 8%
• Clinical Outcomes 8%
• Peripheral Compartment 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Pharmacokinetics 100%
• Clofarabine 100%
• Elimination 16%
• Population Study 8%
• Nucleoside Analog 8%
• Adverse Event 8%
• Disease 8%
• Nucleoside 8%
• Monotherapy 8%
• Fludarabine 8%