Population Pharmacokinetic Model of N-Acetylcysteine During Periods of Recurrent Hypoglycemia in Healthy Volunteers

Keyphrases

• Healthy Volunteers 100%
• N-acetylcysteine 100%
• Population Pharmacokinetic Model 100%
• Recurrent Hypoglycemia 100%
• Hypoglycemia 30%
• Hypoglycemia Unawareness 20%
• Glutathione 20%
• Cysteine 20%
• Volume of Distribution 20%
• Counterregulatory Response 20%
• Placebo-controlled 10%
• Pharmacokinetics 10%
• Oxidative Stress 10%
• Placebo 10%
• Biotransformation 10%
• Healthy Individuals 10%
• Plasma Samples 10%
• Concentration-dependent 10%
• Pharmacokinetic Model 10%
• Blood Glucose 10%
• Disulfide Bond 10%
• Central Compartment 10%
• Distribution Estimates 10%
• Induced Oxidative Stress 10%
• Reducing Agent 10%
• Glucose Threshold 10%
• Hypoglycemia-associated Autonomic Failure 10%
• Hypoglycemic Episodes 10%
• PK Parameters 10%
• Specified Time 10%
• Whole Blood Sample 10%
• Peripheral Compartment 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Normal Human 100%
• Acetylcysteine 100%
• Hypoglycemia 100%
• Pharmacokinetics 100%
• Placebo 20%
• Cysteine 20%
• Glutathione 20%
• Volume of Distribution 20%
• Antidiabetic Agent 10%
• Reducing Agent 10%
• Autonomic Dysfunction 10%
• Experimental Hypoglycemia 10%
• Disulfide Bond 10%

Immunology and Microbiology

• Normal Human 100%
• Pharmacokinetics 100%
• Blood Plasma 66%
• Awareness 66%
• Oxidative Stress 66%
• Glucose Blood Level 33%
• Biotransformation 33%
• Disulfide Bond 33%