Population code for tracking velocity based on cerebellar Purkinje cell simple spike firing in monkeys

Jonathon D. Coltz; Michael T V Johnson; Timothy J. Ebner

doi:10.1016/S0304-3940(00)01571-8

Population code for tracking velocity based on cerebellar Purkinje cell simple spike firing in monkeys

Jonathon D. Coltz
, Michael T V Johnson
, Timothy J. Ebner

Neuroscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Velocity is an important determinant of the simple spike discharge of cerebellar Purkinje cells. In a previous study, Purkinje cells in the intermediate and lateral cerebellum recorded during manual tracking were found to be tuned to a combination of direction and speed, (i.e. preferred velocity). In this study a population analysis of this simple spike discharge was used to determine whether the velocity of tracking could be predicted. For the majority (30/32) of direction-speed combinations, the population response accurately specified the target velocity. A temporal analysis showed how the population response gradually converged to the required velocity 200 ms prior to the onset of tracking. Therefore, the simple spike discharge of a Purkinje cell ensemble contains sufficient information to reconstruct target velocity, providing support for the hypothesis that the cerebellum controls or signals movement velocity. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Neuroscience Letters
Volume	296
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(00)01571-8
State	Published - Dec 15 2000

Bibliographical note

Funding Information:
We wish to thank M. McPhee for assistance with graphics and histology and B. Welter and L. King for help with manuscript preparation. E. Ebner assisted in programming. This work was supported by National Institutes of Health grants 5R01-NS-18118 and F31-MH-1430, a National Science Foundation Grant, IBN-9873478 and a grant from the Human Frontier Science Program.

Keywords

Cerebellum
Primate
Purkinje cells
Pursuit-tracking
Regression
Simple spike
Velocity

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10.1016/S0304-3940(00)01571-8

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title = "Population code for tracking velocity based on cerebellar Purkinje cell simple spike firing in monkeys",

abstract = "Velocity is an important determinant of the simple spike discharge of cerebellar Purkinje cells. In a previous study, Purkinje cells in the intermediate and lateral cerebellum recorded during manual tracking were found to be tuned to a combination of direction and speed, (i.e. preferred velocity). In this study a population analysis of this simple spike discharge was used to determine whether the velocity of tracking could be predicted. For the majority (30/32) of direction-speed combinations, the population response accurately specified the target velocity. A temporal analysis showed how the population response gradually converged to the required velocity 200 ms prior to the onset of tracking. Therefore, the simple spike discharge of a Purkinje cell ensemble contains sufficient information to reconstruct target velocity, providing support for the hypothesis that the cerebellum controls or signals movement velocity. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Cerebellum, Primate, Purkinje cells, Pursuit-tracking, Regression, Simple spike, Velocity",

author = "Coltz, \{Jonathon D.\} and Johnson, \{Michael T V\} and Ebner, \{Timothy J.\}",

note = "Funding Information: We wish to thank M. McPhee for assistance with graphics and histology and B. Welter and L. King for help with manuscript preparation. E. Ebner assisted in programming. This work was supported by National Institutes of Health grants 5R01-NS-18118 and F31-MH-1430, a National Science Foundation Grant, IBN-9873478 and a grant from the Human Frontier Science Program.",

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AU - Coltz, Jonathon D.

AU - Johnson, Michael T V

AU - Ebner, Timothy J.

N1 - Funding Information: We wish to thank M. McPhee for assistance with graphics and histology and B. Welter and L. King for help with manuscript preparation. E. Ebner assisted in programming. This work was supported by National Institutes of Health grants 5R01-NS-18118 and F31-MH-1430, a National Science Foundation Grant, IBN-9873478 and a grant from the Human Frontier Science Program.

PY - 2000/12/15

Y1 - 2000/12/15

N2 - Velocity is an important determinant of the simple spike discharge of cerebellar Purkinje cells. In a previous study, Purkinje cells in the intermediate and lateral cerebellum recorded during manual tracking were found to be tuned to a combination of direction and speed, (i.e. preferred velocity). In this study a population analysis of this simple spike discharge was used to determine whether the velocity of tracking could be predicted. For the majority (30/32) of direction-speed combinations, the population response accurately specified the target velocity. A temporal analysis showed how the population response gradually converged to the required velocity 200 ms prior to the onset of tracking. Therefore, the simple spike discharge of a Purkinje cell ensemble contains sufficient information to reconstruct target velocity, providing support for the hypothesis that the cerebellum controls or signals movement velocity. (C) 2000 Elsevier Science Ireland Ltd.

AB - Velocity is an important determinant of the simple spike discharge of cerebellar Purkinje cells. In a previous study, Purkinje cells in the intermediate and lateral cerebellum recorded during manual tracking were found to be tuned to a combination of direction and speed, (i.e. preferred velocity). In this study a population analysis of this simple spike discharge was used to determine whether the velocity of tracking could be predicted. For the majority (30/32) of direction-speed combinations, the population response accurately specified the target velocity. A temporal analysis showed how the population response gradually converged to the required velocity 200 ms prior to the onset of tracking. Therefore, the simple spike discharge of a Purkinje cell ensemble contains sufficient information to reconstruct target velocity, providing support for the hypothesis that the cerebellum controls or signals movement velocity. (C) 2000 Elsevier Science Ireland Ltd.

KW - Cerebellum

KW - Primate

KW - Purkinje cells

KW - Pursuit-tracking

KW - Regression

KW - Simple spike

KW - Velocity

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DO - 10.1016/S0304-3940(00)01571-8

M3 - Article

C2 - 11099819

AN - SCOPUS:0034672312

SN - 0304-3940

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Population code for tracking velocity based on cerebellar Purkinje cell simple spike firing in monkeys

Abstract

Bibliographical note

Keywords

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