Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease

Luke Martin; William Peche; Kathryn Peterson; Yuan Wan; Stephanie Chan; Ryan Morton; Chong Zhang; Angela P. Presson; James Hotaling

doi:10.1038/ajg.2017.279

Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease

Luke Martin, William Peche, Kathryn Peterson, Yuan Wan, Stephanie Chan, Ryan Morton, Chong Zhang, Angela P. Presson, James Hotaling

Surgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

OBJECTIVES:Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes.METHODS:From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately.RESULTS:Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CD patients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24).CONCLUSIONS:We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.

Original language	English (US)
Pages (from-to)	1722-1727
Number of pages	6
Journal	American Journal of Gastroenterology
Volume	112
Issue number	11
DOIs	https://doi.org/10.1038/ajg.2017.279
State	Published - Nov 1 2017

Bibliographical note

Funding Information:
Guarantor of the article: Luke Martin, MD. Specific author contributions: LM, WP, KP, and JH: conception, design, data acquisition, interpretation, drafting, revisions, and approval. CZ and Presson: design, analysis, interpretation, drafting, revisions, and approval. SC and RM: data acquisition, interpretation, revisions, and approval. YW: design, data acquisition, interpretation, revisions, and approval. Financial support: This study was funded by the co-author, WP, and by the Department of Surgery at the University of Utah. Indirect financial support in part for the statistical analysis and the Utah Population Database are as follows: Utah Population Database Support: “We thank the Pedigree and Population Resource of the Huntsman Cancer Institute, University of Utah (funded in part by the Huntsman Cancer Foundation) for its role in the ongoing collection, maintenance and support of the Utah Population Database (UPDB). We also acknowledge partial support for the UPDB through grant P30 CA2014 from the National Cancer Institute, University of Utah and from the University of Utah’s Program in Personalized Health and Center for Clinical and Translational Science.” “We thank the University of Utah Center for Clinical and Translational Science (CCTS) (funded by NIH Clinical and Translational Science Awards), the Pedigree and Population Resource, University of Utah Information Technology Services and Biomedical Informatics Core for establishing the Master Subject Index between the Utah Population Database, the University of Utah Health Sciences Center and Intermountain Health Care.” “Research was supported by the NCRR grant, “Sharing Statewide Health Data for Genetic Research” (R01 RR021746, G. Mineau, PI) with additional support from the Utah State Department of Health and the University of Utah.” Statistical Section Support: “The statistical section was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 5UL1TR001067-02 (formerly 8UL1TR000105 and UL1RR025764).” Potential competing interests: None.

Publisher Copyright:
© 2017 by the American College of Gastroenterology.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease. / Martin, Luke; Peche, William; Peterson, Kathryn; Wan, Yuan; Chan, Stephanie; Morton, Ryan; Zhang, Chong; Presson, Angela P.; Hotaling, James.

In: American Journal of Gastroenterology, Vol. 112, No. 11, 01.11.2017, p. 1722-1727.

Research output: Contribution to journal › Article › peer-review

@article{7f09c1dc4c4a4902b14335e2eb8b58b9,

title = "Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease",

abstract = "OBJECTIVES:Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes.METHODS:From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately.RESULTS:Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CD patients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24).CONCLUSIONS:We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.",

author = "Luke Martin and William Peche and Kathryn Peterson and Yuan Wan and Stephanie Chan and Ryan Morton and Chong Zhang and Presson, {Angela P.} and James Hotaling",

note = "Funding Information: Guarantor of the article: Luke Martin, MD. Specific author contributions: LM, WP, KP, and JH: conception, design, data acquisition, interpretation, drafting, revisions, and approval. CZ and Presson: design, analysis, interpretation, drafting, revisions, and approval. SC and RM: data acquisition, interpretation, revisions, and approval. YW: design, data acquisition, interpretation, revisions, and approval. Financial support: This study was funded by the co-author, WP, and by the Department of Surgery at the University of Utah. Indirect financial support in part for the statistical analysis and the Utah Population Database are as follows: Utah Population Database Support: “We thank the Pedigree and Population Resource of the Huntsman Cancer Institute, University of Utah (funded in part by the Huntsman Cancer Foundation) for its role in the ongoing collection, maintenance and support of the Utah Population Database (UPDB). We also acknowledge partial support for the UPDB through grant P30 CA2014 from the National Cancer Institute, University of Utah and from the University of Utah{\textquoteright}s Program in Personalized Health and Center for Clinical and Translational Science.” “We thank the University of Utah Center for Clinical and Translational Science (CCTS) (funded by NIH Clinical and Translational Science Awards), the Pedigree and Population Resource, University of Utah Information Technology Services and Biomedical Informatics Core for establishing the Master Subject Index between the Utah Population Database, the University of Utah Health Sciences Center and Intermountain Health Care.” “Research was supported by the NCRR grant, “Sharing Statewide Health Data for Genetic Research” (R01 RR021746, G. Mineau, PI) with additional support from the Utah State Department of Health and the University of Utah.” Statistical Section Support: “The statistical section was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 5UL1TR001067-02 (formerly 8UL1TR000105 and UL1RR025764).” Potential competing interests: None. Publisher Copyright: {\textcopyright} 2017 by the American College of Gastroenterology. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = nov,

day = "1",

doi = "10.1038/ajg.2017.279",

language = "English (US)",

volume = "112",

pages = "1722--1727",

journal = "American Journal of Gastroenterology",

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T1 - Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease

AU - Martin, Luke

AU - Peche, William

AU - Peterson, Kathryn

AU - Wan, Yuan

AU - Chan, Stephanie

AU - Morton, Ryan

AU - Zhang, Chong

AU - Presson, Angela P.

AU - Hotaling, James

N1 - Funding Information: Guarantor of the article: Luke Martin, MD. Specific author contributions: LM, WP, KP, and JH: conception, design, data acquisition, interpretation, drafting, revisions, and approval. CZ and Presson: design, analysis, interpretation, drafting, revisions, and approval. SC and RM: data acquisition, interpretation, revisions, and approval. YW: design, data acquisition, interpretation, revisions, and approval. Financial support: This study was funded by the co-author, WP, and by the Department of Surgery at the University of Utah. Indirect financial support in part for the statistical analysis and the Utah Population Database are as follows: Utah Population Database Support: “We thank the Pedigree and Population Resource of the Huntsman Cancer Institute, University of Utah (funded in part by the Huntsman Cancer Foundation) for its role in the ongoing collection, maintenance and support of the Utah Population Database (UPDB). We also acknowledge partial support for the UPDB through grant P30 CA2014 from the National Cancer Institute, University of Utah and from the University of Utah’s Program in Personalized Health and Center for Clinical and Translational Science.” “We thank the University of Utah Center for Clinical and Translational Science (CCTS) (funded by NIH Clinical and Translational Science Awards), the Pedigree and Population Resource, University of Utah Information Technology Services and Biomedical Informatics Core for establishing the Master Subject Index between the Utah Population Database, the University of Utah Health Sciences Center and Intermountain Health Care.” “Research was supported by the NCRR grant, “Sharing Statewide Health Data for Genetic Research” (R01 RR021746, G. Mineau, PI) with additional support from the Utah State Department of Health and the University of Utah.” Statistical Section Support: “The statistical section was supported by the University of Utah Study Design and Biostatistics Center, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant 5UL1TR001067-02 (formerly 8UL1TR000105 and UL1RR025764).” Potential competing interests: None. Publisher Copyright: © 2017 by the American College of Gastroenterology. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - OBJECTIVES:Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes.METHODS:From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately.RESULTS:Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CD patients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24).CONCLUSIONS:We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.

AB - OBJECTIVES:Crohn's disease (CD) and ulcerative colitis (UC) impact an estimated 350,000 reproductive age men in the United States. The reproductive consequences are largely unknown. The objective of this study was to evaluate the effects of CD and UC on reproductive outcomes.METHODS:From the Utah Population Database, we identified a cohort of male patients with CD (1,245) and UC (1,368). Male-sibling controls were identified, and birth outcome data from offspring were obtained. Analyses for CD and UC were completed separately.RESULTS:Among UC patients (473) with at least one male sibling (1,020), 66% had offspring, which was not different compared with siblings (61%, P=0.16). Birth outcomes were not different between UC patients and male siblings: congenital malformations (UC 6% vs. 6%, P=0.99), perinatal complications (UC 35% vs. 31%, P=0.23), mean birth weight (UC 3,347 vs. 3,357 g, P=0.53), mean length of gestation (UC 39.0 vs. 39.1 weeks, P=0.54). Among CD patients (421) with at least one male sibling (833), 58% had offspring, which did not differ compared with siblings (57%, P=0.77). Similarly, there were no differences in partner birth outcomes: congenital malformations (CD 7% vs. 6%, P=0.27), perinatal complications (CD 35% vs. 32%, P=0.12), mean birth weight (CD 3,276 vs. 3,324 g, P=0.13), or mean length of gestation (38.8 vs. 39 weeks, P=0.24).CONCLUSIONS:We found no differences in paternity rate or female partner birth outcomes in Utah men with UC or CD compared with male-sibling controls. UC and CD do not appear to affect the reproductive outcomes of men in Utah.

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Population Based Paternity Rate and Partner Birth Outcomes among Utah Men with Inflammatory Bowel Disease

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