Abstract
Original and literature data on mechanism of action and clinical application of polyoxidonium are reviewed. This novel immunomodulator produced in Russia is a high-molecular physiologically active compound with marked immunotropic activity. Polyoxidonium affects all the mechanisms protecting the body from foreign antigenic agents. It is a true immunomodulator as it enhances low and inhibits overactivated immunity. Polyoxidonium targets are phagocytic cells and natural killers. It stimulates or costimulates production of IL-1β, IL-6, TNF-α and β-interferon. Polyoxidonium potentiates phagocyte ability to kill bacteria. In deficient humoral immunity polyoxidonium stimulates production of antibodies. Moreover, polyoxidonium acts as detoxicant, antioxidant and membrane-stabilizing agent. All the above effects of polyoxidonium make it a unique adjuvant in combined treatment of acute and chronic infections of any etiology, in immunorehabilitation of cancer patients, in the treatment of secondary immunodeficiencies simultaneously with etiotropic drugs.
Original language | English (US) |
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Pages (from-to) | 24-28 |
Number of pages | 5 |
Journal | Immunologiya |
Issue number | 5 |
State | Published - 2000 |
Externally published | Yes |