TY - JOUR
T1 - Polymyxins
T2 - Pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications
AU - Hermsen, Elizabeth D.
AU - Sullivan, Christopher J
AU - Rotschafer, John C
PY - 2003/9
Y1 - 2003/9
N2 - Although the polymyxins seem attractive because of their unique structure and mechanism of action, relatively little is known about this group of antibiotics. Much of the available information is from a different era of medical practice when the manipulation of dosing strategies, or optimization of pharmacodynamic parameters, was not commonplace. Moreover, the more recent information that is available is limited in scope with regards to patient populations and microorganisms.
AB - Although the polymyxins seem attractive because of their unique structure and mechanism of action, relatively little is known about this group of antibiotics. Much of the available information is from a different era of medical practice when the manipulation of dosing strategies, or optimization of pharmacodynamic parameters, was not commonplace. Moreover, the more recent information that is available is limited in scope with regards to patient populations and microorganisms.
UR - http://www.scopus.com/inward/record.url?scp=0345802550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345802550&partnerID=8YFLogxK
U2 - 10.1016/S0891-5520(03)00058-8
DO - 10.1016/S0891-5520(03)00058-8
M3 - Review article
C2 - 14711076
AN - SCOPUS:0345802550
VL - 17
SP - 545
EP - 562
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
SN - 0891-5520
IS - 3
ER -
