Polymyxins: Pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications

Elizabeth D. Hermsen; Christopher J Sullivan; John C Rotschafer

doi:10.1016/S0891-5520(03)00058-8

Polymyxins: Pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications

Elizabeth D. Hermsen, Christopher J Sullivan, John C Rotschafer

Research output: Contribution to journal › Review article

82 Scopus citations

Abstract

Although the polymyxins seem attractive because of their unique structure and mechanism of action, relatively little is known about this group of antibiotics. Much of the available information is from a different era of medical practice when the manipulation of dosing strategies, or optimization of pharmacodynamic parameters, was not commonplace. Moreover, the more recent information that is available is limited in scope with regards to patient populations and microorganisms.

Original language	English (US)
Pages (from-to)	545-562
Number of pages	18
Journal	Infectious Disease Clinics of North America
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S0891-5520(03)00058-8
State	Published - Sep 2003

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Hermsen, E. D., Sullivan, C. J., & Rotschafer, J. C. (2003). Polymyxins: Pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications. Infectious Disease Clinics of North America, 17(3), 545-562. https://doi.org/10.1016/S0891-5520(03)00058-8

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