Polymyxins: Pharmacology, pharmacokinetics, pharmacodynamics, and clinical applications

Elizabeth D. Hermsen, Christopher J Sullivan, John C Rotschafer

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Although the polymyxins seem attractive because of their unique structure and mechanism of action, relatively little is known about this group of antibiotics. Much of the available information is from a different era of medical practice when the manipulation of dosing strategies, or optimization of pharmacodynamic parameters, was not commonplace. Moreover, the more recent information that is available is limited in scope with regards to patient populations and microorganisms.

Original languageEnglish (US)
Pages (from-to)545-562
Number of pages18
JournalInfectious Disease Clinics of North America
Issue number3
StatePublished - Sep 2003


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