Polymorphous Adenocarcinoma, Low Grade Variant, Colliding with a Neurofibroma

Nikolaos G. Katsoulas, Konstantinos I. Tosios, Hannah Afwerke Lynch, Rachel Uppgaard, Ioannis G. Koutlas

Research output: Contribution to journalArticlepeer-review


Collision tumors, composed of two distinct benign or malignant neoplasms, are rarely reported in the oral cavity. We present a case of a 61-year-old female with an asymptomatic non-demarcated lump on the soft palate of unknown duration. An incisional biopsy revealed the presence of two neoplastic populations, a neurofibroma that was partially infiltrated by a polymorphous adenocarcinoma, low-grade variant. Total surgical excision was performed, with uneventful follow-up period. The development of collision tumors may be incidental, although molecular events may influence the pathogenetic mechanism of the phenomenon.

Original languageEnglish (US)
JournalHead and Neck Pathology
Early online dateSep 1 2021
StatePublished - Sep 1 2021

Bibliographical note

Funding Information:
The study was funded by the University of Minnesota Oral Pathology Research Fund (internal funding).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


  • CD34
  • Collision tumor
  • Epithelial membrane antigen
  • Glut-1
  • Neurofibroma
  • Palate
  • Polymorphous adenocarcinoma


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