Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels

Christopher S. Carlson; Shelley Force Aldred; Philip K. Lee; Russell P. Tracy; Stephen M. Schwartz; Mark Rieder; Kiang Liu; O. Dale Williams; Carlos Iribarren; E. Cora Lewis; Myriam Fornage; Eric Boerwinkle; Myron Gross; Cashell Jaquish; Deborah A. Nickerson; Richard M. Myers; David S. Siscovick; Alexander P. Reiner

doi:10.1086/431366

Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels

Christopher S. Carlson
, Shelley Force Aldred
, Philip K. Lee
, Russell P. Tracy
, Stephen M. Schwartz
, Mark Rieder
, Kiang Liu
, O. Dale Williams
, Carlos Iribarren
, E. Cora Lewis
, Myriam Fornage
, Eric Boerwinkle
, Myron Gross
, Cashell Jaquish
, Deborah A. Nickerson
, Richard M. Myers
, David S. Siscovick
, Alexander P. Reiner

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

296 Scopus citations

Abstract

Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

Original language	English (US)
Pages (from-to)	64-77
Number of pages	14
Journal	American Journal of Human Genetics
Volume	77
Issue number	1
DOIs	https://doi.org/10.1086/431366
State	Published - Jul 2005

Bibliographical note

Funding Information:
This work was supported by Inflammatory Genomics and Atherosclerosis Prevention ancillary CARDIA grant HL71017 (to D.S.), by CARDIA contracts N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, and N01-HC-05187 from NHLBI, and by NHLBI Program for Genomic Applications grants HL66682 and HL66642 (to D.N. and M.R.).

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SDG 3 Good Health and Well-being

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10.1086/431366

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Carlson, C. S., Aldred, S. F., Lee, P. K., Tracy, R. P., Schwartz, S. M., Rieder, M., Liu, K., Williams, O. D., Iribarren, C., Lewis, E. C., Fornage, M., Boerwinkle, E., Gross, M., Jaquish, C., Nickerson, D. A., Myers, R. M., Siscovick, D. S., & Reiner, A. P. (2005). Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. American Journal of Human Genetics, 77(1), 64-77. https://doi.org/10.1086/431366

Carlson, CS, Aldred, SF, Lee, PK, Tracy, RP, Schwartz, SM, Rieder, M, Liu, K, Williams, OD, Iribarren, C, Lewis, EC, Fornage, M, Boerwinkle, E, Gross, M, Jaquish, C, Nickerson, DA, Myers, RM, Siscovick, DS & Reiner, AP 2005, 'Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels', American Journal of Human Genetics, vol. 77, no. 1, pp. 64-77. https://doi.org/10.1086/431366

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title = "Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels",

abstract = "Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.",

author = "Carlson, \{Christopher S.\} and Aldred, \{Shelley Force\} and Lee, \{Philip K.\} and Tracy, \{Russell P.\} and Schwartz, \{Stephen M.\} and Mark Rieder and Kiang Liu and Williams, \{O. Dale\} and Carlos Iribarren and Lewis, \{E. Cora\} and Myriam Fornage and Eric Boerwinkle and Myron Gross and Cashell Jaquish and Nickerson, \{Deborah A.\} and Myers, \{Richard M.\} and Siscovick, \{David S.\} and Reiner, \{Alexander P.\}",

note = "Funding Information: This work was supported by Inflammatory Genomics and Atherosclerosis Prevention ancillary CARDIA grant HL71017 (to D.S.), by CARDIA contracts N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, and N01-HC-05187 from NHLBI, and by NHLBI Program for Genomic Applications grants HL66682 and HL66642 (to D.N. and M.R.). ",

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doi = "10.1086/431366",

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AU - Carlson, Christopher S.

AU - Aldred, Shelley Force

AU - Lee, Philip K.

AU - Tracy, Russell P.

AU - Schwartz, Stephen M.

AU - Rieder, Mark

AU - Liu, Kiang

AU - Williams, O. Dale

AU - Iribarren, Carlos

AU - Lewis, E. Cora

AU - Fornage, Myriam

AU - Boerwinkle, Eric

AU - Gross, Myron

AU - Jaquish, Cashell

AU - Nickerson, Deborah A.

AU - Myers, Richard M.

AU - Siscovick, David S.

AU - Reiner, Alexander P.

N1 - Funding Information: This work was supported by Inflammatory Genomics and Atherosclerosis Prevention ancillary CARDIA grant HL71017 (to D.S.), by CARDIA contracts N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, and N01-HC-05187 from NHLBI, and by NHLBI Program for Genomic Applications grants HL66682 and HL66642 (to D.N. and M.R.).

PY - 2005/7

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N2 - Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

AB - Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

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Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels

Abstract

Bibliographical note

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