Polymorphism in the rhesus macaque (Macaca mulatta) NRAMP1 gene: Lack of an allelic association to tuberculosis susceptibility

Amos S. Deinard, Nicholas W. Lerche, David Glenn Smith

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Although previous tuberculosis (TB) research has suggested that underlying genetic factors influence a host's response and ability to survive Mycobacterium infection, only recently has a gene been identified, the 'natural resistance-associated macrophage protein 1' (NRAMP1) gene, which provides a degree of natural resistance to infection by some Mycobacterium species. To date, however, the role that NRAMP1 may play in resistance to Mycobacterium infection has only been examined in mouse and man. Here, we present data generated at NRAMP1 among a group of rhesus macaques (Macaca mulatta) that were euthanized because of an outbreak of Mycobacterium tuberculosis during quarantine. Data were also generated on unrelated (and healthy) rhesus macaques in order to better determine the frequency and degree of genetic polymorphism within Macaca at the NRAMP1 locus. These data represent the first study designed to examine the role that NRAMP1 may play in TB susceptibility among rhesus macaques.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalJournal of Medical Primatology
Volume31
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Macaque
  • NRAMP1
  • Tuberculosis susceptibility

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