Polymicrogyria includes fusion of the molecular layer and decreased neuronal populations but normal cortical laminar organization

Alexander R. Judkins, Daniel Martinez, Pamela Ferreira, William B. Dobyns, Jeffrey A. Golden

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Malformations of cortical development are frequently identified in surgical resections for intractable epilepsy. Among the more frequently identified are cortical dysplasia, pachygyria, and polymicrogyria. The pathogenesis of these common developmental anomalies remains uncertain. Polymicrogyria is particularly vexing because there are multiple described forms (2, 4, and 6 layers) that have been attributed to multiple etiologies (e.g. ischemic, genetic, infectious, and toxic). We reviewed thepathology in 19 cases and performed cortical laminar analysis in 10 ofthese cases. Our data indicate that a defining feature of polymicrogyriais fusion of the molecular layer and that most often there is a well-defined gray matter-white matter junction. Unexpectedly, the cortical laminae were normally positioned, but there were reduced neuronal populations within these laminae, particularly in the subgranular layers. On the basis of these data, we propose that the categorization of polymicrogyria according to the number of lamina is artificial and should beabandoned, and polymicrogyria should be defined according to the presence or absence of coexisting neuropathological features. Furthermore, our data indicate that polymicrogyria is not a cell migration disorder, rather it should be considered a postmigration malformation ofcortical development.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalJournal of neuropathology and experimental neurology
Issue number6
StatePublished - Jun 2011
Externally publishedYes


  • Cell migration
  • Cerebral cortex
  • Cortical lamina
  • Malformation of cortical development
  • Polymicrogyria
  • Seizures


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