Polymers for DNA Vaccine Delivery

Mingming Zhang, Yanhang Hong, Wenjuan Chen, Chun Wang

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


DNA vaccine is a third generation vaccine type based on concepts and techniques of molecular biology. It can closely mimic live infections and induce both antibody and cell mediated immune responses and thus has much potential for treating chronic viral infection and cancer. How do we transport the DNA vaccine to the right target cells in lymphoid tissues and organs? How do we achieve high and robust gene transfection efficiency while simultaneously inducing DC maturation and antigen presentation? These questions pose significant challenges and addressing them may require serious efforts in developing better biomaterials as carriers. This review is dedicated to the discussion of polymers as nanoscale carriers for the DNA vaccine. We summarize recent advances in polymer science and engineering to overcome multilevel hurdles for DNA vaccine delivery and conclude with thoughts on challenges and opportunities that may shape the future of polymers in DNA vaccination.

Original languageEnglish (US)
Pages (from-to)108-125
Number of pages18
JournalACS Biomaterials Science and Engineering
Issue number2
StatePublished - Feb 13 2017

Bibliographical note

Funding Information:
C.W. acknowledges funding from the NIH/NCI (grant R01CA129189).

Publisher Copyright:
© 2016 American Chemical Society.


  • DNA vaccine
  • gene delivery
  • immunotherapy
  • polymers


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