Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

Yuhui Li, Junguang Yu, Shenye Hu, Zhenxuan Chen, Mark Sacchetti, Changquan Calvin Sun, Lian Yu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be deposited on the surface of amorphous indomethacin by electrostatic deposition, leading to significant improvement of physical stability, wetting by aqueous media, dissolution rate, powder flow, and tabletability. The coating condition was chosen so that the positively charged polymer deposits on the negatively charged drug. Chitosan coating is superior to gelatin coating with respect to stability against crystallization and agglomeration of coated particles.

Original languageEnglish (US)
Pages (from-to)1305-1311
Number of pages7
JournalMolecular pharmaceutics
Volume16
Issue number3
DOIs
StatePublished - Mar 4 2019

Bibliographical note

Funding Information:
We thank the Bill and Melinda Gates Foundation for financial support, R. Teerekapibal for experimental assistance, and Niya Bowers, Phil Goliber, and Ellen Harrington for helpful discussions.

Publisher Copyright:
© 2019 American Chemical Society.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • amorphous drug
  • chitosan
  • crystallization
  • dissolution
  • indomethacin
  • powder flow
  • surface coating
  • tabletability

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