Polymer Microparticles for Nucleic Acid Delivery

Timothy R Pearce, Jared Hierman, Chun Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationDelivery Technologies for Biopharmaceuticals
Subtitle of host publicationPeptides, Proteins, Nucleic Acids and Vaccines
PublisherJohn Wiley & Sons, Ltd
Number of pages23
ISBN (Print)9780470723388
StatePublished - Dec 11 2009


  • Cryopreparation- protecting DNA from degradation by shear stress
  • Emulsion spray-drying- alternative method to standard double emulsion technique
  • Microparticle fabrication techniques and optimization of microparticle properties
  • Microparticles- general strategies and fabrication
  • PLGA microparticle performance for nucleic acid delivery
  • PLGA- random copolymer of lactic acid and glycolic acid
  • Polycation incorporation into PLGA microparticle formulation
  • Polymer microparticles as formulation strategy for delivering nucleic acids
  • Polymer microparticles for nucleic acid delivery
  • Polymer of choice for microparticles- poly(lactic-co-glycolic acid) polymer, or PLGA

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