Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols nad alcohols

Ashok Rao Tunoori; Dinah Dutta; Gunda I. Georg

doi:10.1016/S0040-4039(98)01988-1

Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols nad alcohols

Ashok Rao Tunoori, Dinah Dutta, Gunda I. Georg

Medicinal Chemistry

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Abstract

The synthesis of aryl ethers from phenols and alcohols using polymer- bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields.

Original language	English (US)
Pages (from-to)	8751-8754
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4039(98)01988-1
State	Published - Nov 26 1998

Bibliographical note

Funding Information:
Acknowledgments: We gratefully acknowledge financial support from the National Cancer Institute (N01-CM-67259), Kansas Technology Enterprise, and the University of Kansas.

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10.1016/S0040-4039(98)01988-1

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title = "Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols nad alcohols",

abstract = "The synthesis of aryl ethers from phenols and alcohols using polymer- bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields.",

author = "Tunoori, {Ashok Rao} and Dinah Dutta and Georg, {Gunda I.}",

note = "Funding Information: Acknowledgments: We gratefully acknowledge financial support from the National Cancer Institute (N01-CM-67259), Kansas Technology Enterprise, and the University of Kansas.",

year = "1998",

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doi = "10.1016/S0040-4039(98)01988-1",

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T2 - Synthesis of aryl ethers from phenols nad alcohols

AU - Tunoori, Ashok Rao

AU - Dutta, Dinah

AU - Georg, Gunda I.

N1 - Funding Information: Acknowledgments: We gratefully acknowledge financial support from the National Cancer Institute (N01-CM-67259), Kansas Technology Enterprise, and the University of Kansas.

PY - 1998/11/26

Y1 - 1998/11/26

N2 - The synthesis of aryl ethers from phenols and alcohols using polymer- bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields.

AB - The synthesis of aryl ethers from phenols and alcohols using polymer- bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields.

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Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols nad alcohols

Abstract

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