Polyionic drug-sensitive membrane electrodes: Principles and practice

Bin Fu; Jong H. Yun; Joyce Wahr; Mark E. Meyerhoff; Victor C. Yang

doi:10.1016/S0169-409X(96)00409-7

Polyionic drug-sensitive membrane electrodes: Principles and practice

Bin Fu, Jong H. Yun, Joyce Wahr, Mark E. Meyerhoff, Victor C. Yang

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Recent advances in the design and applications of polymer membrane-based potentiometric sensors for measuring polyionic drugs (i.e. heparin and protamine) are reviewed. The underlying principles for potentiometric polyion sensing are described. The utility of newly developed heparin and protamine sensors is demonstrated via both fundamental and practical applications.

Original language	English (US)
Pages (from-to)	215-223
Number of pages	9
Journal	Advanced Drug Delivery Reviews
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/S0169-409X(96)00409-7
State	Published - Oct 11 1996

Bibliographical note

Funding Information:
Financial support from National Institutes of Health (grant HL 38353 and GM 28882) and from Medtronic HemoTec (Parker, CO) are gratefully acknowledged.

Keywords

heparin
ion-selective electrodes (ISE)
macromolecular binding constants
potentiometric sensors
protamine
protamine titration
protease activity

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10.1016/S0169-409X(96)00409-7

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title = "Polyionic drug-sensitive membrane electrodes: Principles and practice",

abstract = "Recent advances in the design and applications of polymer membrane-based potentiometric sensors for measuring polyionic drugs (i.e. heparin and protamine) are reviewed. The underlying principles for potentiometric polyion sensing are described. The utility of newly developed heparin and protamine sensors is demonstrated via both fundamental and practical applications.",

keywords = "heparin, ion-selective electrodes (ISE), macromolecular binding constants, potentiometric sensors, protamine, protamine titration, protease activity",

author = "Bin Fu and Yun, {Jong H.} and Joyce Wahr and Meyerhoff, {Mark E.} and Yang, {Victor C.}",

note = "Funding Information: Financial support from National Institutes of Health (grant HL 38353 and GM 28882) and from Medtronic HemoTec (Parker, CO) are gratefully acknowledged.",

year = "1996",

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doi = "10.1016/S0169-409X(96)00409-7",

language = "English (US)",

volume = "21",

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T1 - Polyionic drug-sensitive membrane electrodes

T2 - Principles and practice

AU - Fu, Bin

AU - Yun, Jong H.

AU - Wahr, Joyce

AU - Meyerhoff, Mark E.

AU - Yang, Victor C.

N1 - Funding Information: Financial support from National Institutes of Health (grant HL 38353 and GM 28882) and from Medtronic HemoTec (Parker, CO) are gratefully acknowledged.

PY - 1996/10/11

Y1 - 1996/10/11

N2 - Recent advances in the design and applications of polymer membrane-based potentiometric sensors for measuring polyionic drugs (i.e. heparin and protamine) are reviewed. The underlying principles for potentiometric polyion sensing are described. The utility of newly developed heparin and protamine sensors is demonstrated via both fundamental and practical applications.

AB - Recent advances in the design and applications of polymer membrane-based potentiometric sensors for measuring polyionic drugs (i.e. heparin and protamine) are reviewed. The underlying principles for potentiometric polyion sensing are described. The utility of newly developed heparin and protamine sensors is demonstrated via both fundamental and practical applications.

KW - heparin

KW - ion-selective electrodes (ISE)

KW - macromolecular binding constants

KW - potentiometric sensors

KW - protamine

KW - protamine titration

KW - protease activity

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DO - 10.1016/S0169-409X(96)00409-7

M3 - Review article

AN - SCOPUS:0030580120

VL - 21

SP - 215

EP - 223

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 3

ER -

Polyionic drug-sensitive membrane electrodes: Principles and practice

Abstract

Bibliographical note

Keywords

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