Poly(C)-binding proteins as transcriptional regulators of gene expression

Hack Sun Choi, Cheol Kyu T Hwang, Kyu Young Song, Ping-Yee Law, Li-Na Wei, Horace H Loh

Research output: Contribution to journalShort surveypeer-review

83 Scopus citations

Abstract

Poly(C)-binding proteins (PCBPs) are generally known as RNA-binding proteins that interact in a sequence-specific fashion with single-stranded poly(C). They can be divided into two groups: hnRNP K and PCBP1-4. These proteins are involved mainly in various posttranscriptional regulations (e.g., mRNA stabilization or translational activation/silencing). In this review, we summarize and discuss how PCBPs act as transcriptional regulators by binding to specific elements in gene promoters that interact with the RNA polymerase II transcription machinery. Transcriptional regulation of PCBPs might itself be regulated by their localization within the cell. For example, activation by p21-activated kinase 1 induces increased nuclear retention of PCBP1, as well as increased promoter activity. PCBPs can function as a signal-dependent and coordinated regulator of transcription in eukaryotic cells. We address the molecular mechanisms by which PCBPs binding to single- and double-stranded DNA mediates gene expression.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume380
Issue number3
DOIs
StatePublished - Mar 13 2009

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health research Grants DA000564, DA001583, DA011806, DA011190, DA007339, K05-DA070554, K05-DA00513 and K05-DA013926 and by the F. & A. Stark Fund of the Minnesota Medical Foundation.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • DNA-binding proteins
  • P21-activated kinase 1
  • Poly(C)-binding proteins
  • Transcriptional regulation

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