Abstract
Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2409-2413 |
| Number of pages | 5 |
| Journal | Journal of General Virology |
| Volume | 73 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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