Polyadenylic:Polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection

A. Adams; M. Mohrman; A. G. Johnson; A. Morin; E. Deschamps de Paillette

doi:10.1099/0022-1317-73-9-2409

Polyadenylic:Polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection

A. Adams, M. Mohrman, A. G. Johnson, A. Morin, E. Deschamps de Paillette

Biomedical Sciences

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Abstract

Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.

Original language	English (US)
Pages (from-to)	2409-2413
Number of pages	5
Journal	Journal of General Virology
Volume	73
Issue number	9
DOIs	https://doi.org/10.1099/0022-1317-73-9-2409
State	Published - 1992

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title = "Polyadenylic:Polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection",

abstract = "Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.",

author = "A. Adams and M. Mohrman and Johnson, {A. G.} and A. Morin and {Deschamps de Paillette}, E.",

year = "1992",

doi = "10.1099/0022-1317-73-9-2409",

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T1 - Polyadenylic:Polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection

AU - Adams, A.

AU - Mohrman, M.

AU - Johnson, A. G.

AU - Morin, A.

AU - Deschamps de Paillette, E.

PY - 1992

Y1 - 1992

N2 - Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.

AB - Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.

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Polyadenylic:Polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection

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