Polarization sensitive optical coherence microscopy for brain imaging

Hui Wang, Taner Akkin, Caroline Magnain, Ruopeng Wang, Jay Dubb, William J. Kostis, Mohammad A. Yaseen, Avilash Cramer, Sava Sakadiae, David Boas

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 μm axial and 1.3 μm transverse resolution to investigate fiber organization and orientation at a finer scale than previously demonstrated with PS-OCT. In a reconstructed mouse brain section, we showed that at the focal depths of 20-70 μm, the PS-OCM reliably identifies the neuronal fibers and quantifies the in-plane orientation.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalOptics Letters
Issue number10
StatePublished - May 15 2016

Bibliographical note

Funding Information:
National Institutes of Health (NIH) (EB015896, EB021018, NS055104, NS091230, EB018464, AG042026); National Science Foundation (NSF) (1510674)

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