Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group

Kevin R. King, Luanda P. Grazette, Dina N. Paltoo, John T. McDevitt, Samuel K. Sia, Paddy M. Barrett, Fred S. Apple, Paul A. Gurbel, Ralph Weissleder, Hilary Leeds, Erin J. Iturriaga, Anupama K. Rao, Bishow Adhikari, Patrice Desvigne-Nickens, Zorina S. Galis, Peter Libby

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalJACC: Basic to Translational Science
Volume1
Issue number1-2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • biomarkers
  • clinical trials
  • precision medicine

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