Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid

Taseera Kabanda; Mark J. Siedner; Jeffrey D. Klausner; Conrad Muzoora; David R. Boulware

doi:10.1093/cid/cit641

Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid

Taseera Kabanda
, Mark J. Siedner
, Jeffrey D. Klausner
, Conrad Muzoora
, David R. Boulware

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R² = 0.7) and predicted 2-and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.

Original language	English (US)
Pages (from-to)	113-116
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	58
Issue number	1
DOIs	https://doi.org/10.1093/cid/cit641
State	Published - Jan 1 2014

Bibliographical note

Funding Information:
Financial support. Research and salary support was provided by the NIAID (U01AI089244, K23AI073192, T32AI007433), the National Institute of Mental Health (K23099916), and the Medical Research Council (UK). Potential conflicts of interest. All authors: No reported conflicts.

Keywords

HIV
cryptococcal meningitis
diagnosis
point-of-care
sub-Saharan Africa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1093/cid/cit641

Find It

Find It at U of M Libraries

Cite this

@article{7feb37b200914b17a3ce05f65a06236d,

title = "Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid",

abstract = "The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100\% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R2 = 0.7) and predicted 2-and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.",

keywords = "HIV, cryptococcal meningitis, diagnosis, point-of-care, sub-Saharan Africa",

author = "Taseera Kabanda and Siedner, \{Mark J.\} and Klausner, \{Jeffrey D.\} and Conrad Muzoora and Boulware, \{David R.\}",

note = "Funding Information: Financial support. Research and salary support was provided by the NIAID (U01AI089244, K23AI073192, T32AI007433), the National Institute of Mental Health (K23099916), and the Medical Research Council (UK). Potential conflicts of interest. All authors: No reported conflicts.",

year = "2014",

month = jan,

day = "1",

doi = "10.1093/cid/cit641",

language = "English (US)",

volume = "58",

pages = "113--116",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid

AU - Kabanda, Taseera

AU - Siedner, Mark J.

AU - Klausner, Jeffrey D.

AU - Muzoora, Conrad

AU - Boulware, David R.

N1 - Funding Information: Financial support. Research and salary support was provided by the NIAID (U01AI089244, K23AI073192, T32AI007433), the National Institute of Mental Health (K23099916), and the Medical Research Council (UK). Potential conflicts of interest. All authors: No reported conflicts.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R2 = 0.7) and predicted 2-and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.

AB - The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R2 = 0.7) and predicted 2-and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.

KW - HIV

KW - cryptococcal meningitis

KW - diagnosis

KW - point-of-care

KW - sub-Saharan Africa

UR - https://www.scopus.com/pages/publications/84891350644

UR - https://www.scopus.com/pages/publications/84891350644#tab=citedBy

U2 - 10.1093/cid/cit641

DO - 10.1093/cid/cit641

M3 - Article

C2 - 24065327

AN - SCOPUS:84891350644

SN - 1058-4838

VL - 58

SP - 113

EP - 116

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this