Pneumonia in HIV-exposed and Infected Children and Association With Malnutrition

Pui Ying Iroh Tam, Matthew O. Wiens, Jerome Kabakyenga, Julius Kiwanuka, Elias Kumbakumba, Peter P. Moschovis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We evaluated the association between HIV exposed-uninfected (HEU) status, malnutrition and risk of death in Ugandan children hospitalized with pneumonia. Both HIV exposure and infection were associated with lower anthropometric indices on univariate analysis, and mid-upper arm circumference was significantly associated with overall mortality (odds ratio (OR), 0.96) in a multivariable model. HIV infection (OR 5.0) but not HEU status was associated with overall mortality. Malnutrition may contribute to poor pneumonia outcomes among HIV-infected and HEU children requiring hospitalization.

Original languageEnglish (US)
Pages (from-to)1011-1013
Number of pages3
JournalThe Pediatric infectious disease journal
Volume37
Issue number10
DOIs
StatePublished - Oct 1 2018

Bibliographical note

Funding Information:
The studies included in the analysis were funded by Grand Challenges Canada, the Thrasher Early Career Award and the National Institutes of Health (5F32HL124951). M.O.W. is supported by a fellowship from Mitacs Canada. This analysis was conducted with support from Harvard Catalyst/The Har-vard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102) and financial contribu-tions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessar-ily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic healthcare centers or the National Institutes of Health.

Funding Information:
The studies included in the analysis were funded by Grand Challenges Canada, the Thrasher Early Career Award and the National Institutes of Health (5F32HL124951). M.O.W. is supported by a fellowship from Mitacs Canada. This analysis was conducted with support from Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102) and financial contributions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic healthcare centers or the National Institutes of Health.

Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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