Pneumonia and host defense in the elderly

Research output: Contribution to journalReview article

Abstract

The population worldwide continues to age, with those over the age of 80 years constituting the fastest-growing sector of the population. As one ages, infectious complications become more frequent, leading to higher rates of hospitalization. This is also true for the lung, where pneumonia is one of the most frequent causes for hospitalization in the elderly and is the number 3 cause of death in the United States. Several unique changes occur with aging, both in the structure and the function of the respiratory system itself and in the immune system, which increase the predisposition and the potential severity of pneumonia as one ages. In this review, we will highlight the risk factors that are associated with the increased incidence of pneumonia in the elderly and will explore the changes that occur with aging, with focus on the innate and the adaptive immune systems that increase their predisposition to infections.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalClinical Pulmonary Medicine
Volume22
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Pneumonia
Immune System
Hospitalization
Respiratory System
Population
Cause of Death
Lung
Incidence
Infection

Keywords

  • Elderly
  • Immune system
  • Pneumonia
  • Risk factors

Cite this

Pneumonia and host defense in the elderly. / Arndt, Patrick.

In: Clinical Pulmonary Medicine, Vol. 22, No. 6, 01.01.2015, p. 271-278.

Research output: Contribution to journalReview article

@article{48d6bf5b4b764c7a804b3b5de70e8dc1,
title = "Pneumonia and host defense in the elderly",
abstract = "The population worldwide continues to age, with those over the age of 80 years constituting the fastest-growing sector of the population. As one ages, infectious complications become more frequent, leading to higher rates of hospitalization. This is also true for the lung, where pneumonia is one of the most frequent causes for hospitalization in the elderly and is the number 3 cause of death in the United States. Several unique changes occur with aging, both in the structure and the function of the respiratory system itself and in the immune system, which increase the predisposition and the potential severity of pneumonia as one ages. In this review, we will highlight the risk factors that are associated with the increased incidence of pneumonia in the elderly and will explore the changes that occur with aging, with focus on the innate and the adaptive immune systems that increase their predisposition to infections.",
keywords = "Elderly, Immune system, Pneumonia, Risk factors",
author = "Patrick Arndt",
year = "2015",
month = "1",
day = "1",
doi = "10.1097/CPM.0000000000000100",
language = "English (US)",
volume = "22",
pages = "271--278",
journal = "Clinical Pulmonary Medicine",
issn = "1068-0640",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Pneumonia and host defense in the elderly

AU - Arndt, Patrick

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The population worldwide continues to age, with those over the age of 80 years constituting the fastest-growing sector of the population. As one ages, infectious complications become more frequent, leading to higher rates of hospitalization. This is also true for the lung, where pneumonia is one of the most frequent causes for hospitalization in the elderly and is the number 3 cause of death in the United States. Several unique changes occur with aging, both in the structure and the function of the respiratory system itself and in the immune system, which increase the predisposition and the potential severity of pneumonia as one ages. In this review, we will highlight the risk factors that are associated with the increased incidence of pneumonia in the elderly and will explore the changes that occur with aging, with focus on the innate and the adaptive immune systems that increase their predisposition to infections.

AB - The population worldwide continues to age, with those over the age of 80 years constituting the fastest-growing sector of the population. As one ages, infectious complications become more frequent, leading to higher rates of hospitalization. This is also true for the lung, where pneumonia is one of the most frequent causes for hospitalization in the elderly and is the number 3 cause of death in the United States. Several unique changes occur with aging, both in the structure and the function of the respiratory system itself and in the immune system, which increase the predisposition and the potential severity of pneumonia as one ages. In this review, we will highlight the risk factors that are associated with the increased incidence of pneumonia in the elderly and will explore the changes that occur with aging, with focus on the innate and the adaptive immune systems that increase their predisposition to infections.

KW - Elderly

KW - Immune system

KW - Pneumonia

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84946746380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946746380&partnerID=8YFLogxK

U2 - 10.1097/CPM.0000000000000100

DO - 10.1097/CPM.0000000000000100

M3 - Review article

AN - SCOPUS:84946746380

VL - 22

SP - 271

EP - 278

JO - Clinical Pulmonary Medicine

JF - Clinical Pulmonary Medicine

SN - 1068-0640

IS - 6

ER -