Ploidy variation in fungi: Polyploidy, aneuploidy, and genome evolution

Robert T. Todd, Anja Forche, Anna Selmecki

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Cellular ploidy is the number of complete sets of chromosomes in a cell. Many eukaryotic species have two (diploid) or more than two (polyploid) sets of chromosomes (1). These diploid and polyploid states are often the result of ancient whole-genome duplication (WGD) or hybridization events that occurred throughout the evolution of plants, animals, and fungi (2 - 4). Ploidy changes also occur during the development of many organisms and can vary within different tissues of the same organism and between individuals of the same species. For example, ploidy changes occur during the sexual cycle of eukaryotes, from haploid gametes to diploid somatic cells. Additionally, some cells continue to increase in ploidy during development, resulting in somatic tissues that have a mixture of diploid and polyploid cells, including human hepatocytes and megakaryocytes (5 - 7). These ongoing, developmentally programmed changes in ploidy are important for viability and are beneficial to many organisms (8), but the mechanisms controlling ploidy and the physiological significance of each ploidy level are not well characterized.

Original languageEnglish (US)
Title of host publicationThe Fungal Kingdom
PublisherWiley
Pages599-618
Number of pages20
ISBN (Electronic)9781683670827
ISBN (Print)9781555819576
DOIs
StatePublished - Sep 5 2017

Bibliographical note

Publisher Copyright:
© 2018 American Society for Microbiology. All rights reserved.

Keywords

  • Asexual ploidy changes
  • Cancer biology
  • Genome evolution
  • Molecular detection
  • Ploidy variation
  • Polyploidy cells
  • Segmental aneuploidy

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