Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE family study

Mary F. Feitosa; Treva Rice; Kari E. North; Aldi Kraja; Tuomo Rankinen; Arthur S. Leon; James S. Skinner; John Blangero; Claude Bouchard; D. C. Rao

doi:10.1016/j.atherosclerosis.2005.06.023

Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE family study

Mary F. Feitosa, Treva Rice, Kari E. North, Aldi Kraja, Tuomo Rankinen, Arthur S. Leon, James S. Skinner, John Blangero, Claude Bouchard, D. C. Rao

Kinesiology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.

Original language	English (US)
Pages (from-to)	426-432
Number of pages	7
Journal	Atherosclerosis
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2005.06.023
State	Published - Apr 2006

Bibliographical note

Funding Information:
The HERITAGE Family Study is supported by the National Heart, Lung, and Blood Institute through the following grants: HL45670 (C. Bouchard, PI), HL47323 (A.S. Leon, PI), HL47317 (D.C. Rao, PI) and HL47327 (J.S. Skinner, PI). It is also supported by a NIH grant to the University of Minnesota Clinical Research Center. A.S. Leon is supported in part by the Henry L. Taylor Professorship in Exercise Science and Health Enhancement. C. Bouchard is partially supported by the George A. Bray Chair in Nutrition. Gratitude is expressed to Dr. Jack Wilmore for his numerous contributions to the HERITAGE Family Study.

Keywords

Exercise
Genetic epidemiology
Lipids obesity
Quantitative trait loci
Risk factors

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10.1016/j.atherosclerosis.2005.06.023

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Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity : The HERITAGE family study. / Feitosa, Mary F.; Rice, Treva; North, Kari E.; Kraja, Aldi; Rankinen, Tuomo; Leon, Arthur S.; Skinner, James S.; Blangero, John; Bouchard, Claude; Rao, D. C.

In: Atherosclerosis, Vol. 185, No. 2, 04.2006, p. 426-432.

Research output: Contribution to journal › Article › peer-review

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title = "Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE family study",

abstract = "Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.",

keywords = "Exercise, Genetic epidemiology, Lipids obesity, Quantitative trait loci, Risk factors",

author = "Feitosa, {Mary F.} and Treva Rice and North, {Kari E.} and Aldi Kraja and Tuomo Rankinen and Leon, {Arthur S.} and Skinner, {James S.} and John Blangero and Claude Bouchard and Rao, {D. C.}",

note = "Funding Information: The HERITAGE Family Study is supported by the National Heart, Lung, and Blood Institute through the following grants: HL45670 (C. Bouchard, PI), HL47323 (A.S. Leon, PI), HL47317 (D.C. Rao, PI) and HL47327 (J.S. Skinner, PI). It is also supported by a NIH grant to the University of Minnesota Clinical Research Center. A.S. Leon is supported in part by the Henry L. Taylor Professorship in Exercise Science and Health Enhancement. C. Bouchard is partially supported by the George A. Bray Chair in Nutrition. Gratitude is expressed to Dr. Jack Wilmore for his numerous contributions to the HERITAGE Family Study.",

year = "2006",

month = apr,

doi = "10.1016/j.atherosclerosis.2005.06.023",

language = "English (US)",

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pages = "426--432",

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T1 - Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity

T2 - The HERITAGE family study

AU - Feitosa, Mary F.

AU - Rice, Treva

AU - North, Kari E.

AU - Kraja, Aldi

AU - Rankinen, Tuomo

AU - Leon, Arthur S.

AU - Skinner, James S.

AU - Blangero, John

AU - Bouchard, Claude

AU - Rao, D. C.

N1 - Funding Information: The HERITAGE Family Study is supported by the National Heart, Lung, and Blood Institute through the following grants: HL45670 (C. Bouchard, PI), HL47323 (A.S. Leon, PI), HL47317 (D.C. Rao, PI) and HL47327 (J.S. Skinner, PI). It is also supported by a NIH grant to the University of Minnesota Clinical Research Center. A.S. Leon is supported in part by the Henry L. Taylor Professorship in Exercise Science and Health Enhancement. C. Bouchard is partially supported by the George A. Bray Chair in Nutrition. Gratitude is expressed to Dr. Jack Wilmore for his numerous contributions to the HERITAGE Family Study.

PY - 2006/4

Y1 - 2006/4

N2 - Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.

AB - Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.

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KW - Genetic epidemiology

KW - Lipids obesity

KW - Quantitative trait loci

KW - Risk factors

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Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE family study

Abstract

Bibliographical note

Keywords

UN SDGs

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