Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

Mu Yang; Hanzhi Wu; Julie Chu; Lucas A. Gabriel; Y. Kim; Karen S. Anderson; Cristina M. Furdui; Ulrich Bierbach

doi:10.1039/c8cc04251a

Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

Mu Yang, Hanzhi Wu, Julie Chu, Lucas A. Gabriel, Y. Kim, Karen S. Anderson, Cristina M. Furdui, Ulrich Bierbach

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

Original language	English (US)
Pages (from-to)	7479-7482
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	54
DOIs	https://doi.org/10.1039/c8cc04251a
State	Published - 2018
Externally published	Yes

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Publisher Copyright:
© 2018 The Royal Society of Chemistry.

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abstract = "Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.",

author = "Mu Yang and Hanzhi Wu and Julie Chu and Gabriel, {Lucas A.} and Y. Kim and Anderson, {Karen S.} and Furdui, {Cristina M.} and Ulrich Bierbach",

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T1 - Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

AU - Yang, Mu

AU - Wu, Hanzhi

AU - Chu, Julie

AU - Gabriel, Lucas A.

AU - Kim, Y.

AU - Anderson, Karen S.

AU - Furdui, Cristina M.

AU - Bierbach, Ulrich

PY - 2018

Y1 - 2018

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AB - Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

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ER -

Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

Abstract

Bibliographical note

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