TY - JOUR
T1 - Platelet-Rich Plasma
T2 - Advances and Controversies in Hair Restoration and Skin Rejuvenation
AU - Kourosh, Arianne Shadi
AU - Santiago Mangual, Kathyana P.
AU - Farah, Ronda S.
AU - Rao, Medha
AU - Hordinsky, Maria K.
AU - Arruda, Suleima
AU - Sadick, Neil
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - BACKGROUNDPlatelet-rich plasma (PRP) and its combined therapeutic modalities have catalyzed new possibilities in dermatology; however, limitations in evidence and lack of consensus remain among clinicians regarding optimal composition, protocol, technique, and application.OBJECTIVETo provide an update and analysis of the evidence for PRP in hair restoration and skin rejuvenation through review of recent available data, highlighting controversies and expert insights to guide future studies, and stimulate discourse and innovations benefitting patients.METHODSA structured review and expert analysis of PubMed publications before October 2023, with a focus on recent literature from January 2020 through October 2023.RESULTS AND CONCLUSIONGrowing literature supports the utility and benefits of PRP and related autologous products for applications for skin and hair, with strongest evidence for androgenetic alopecia and skin rejuvenation. However, this is limited by lack of consensus regarding best practices and protocols. Randomized, controlled trials with uniform metrics comparing outcomes of various compositions of autologous blood products, preparation methods, dosimetry, and frequency of treatments are still required. This will allow the medical discourse to grow beyond the realm of expert opinion into consensus, standardization, and more wide spread adoption of best practices that will benefit patients.
AB - BACKGROUNDPlatelet-rich plasma (PRP) and its combined therapeutic modalities have catalyzed new possibilities in dermatology; however, limitations in evidence and lack of consensus remain among clinicians regarding optimal composition, protocol, technique, and application.OBJECTIVETo provide an update and analysis of the evidence for PRP in hair restoration and skin rejuvenation through review of recent available data, highlighting controversies and expert insights to guide future studies, and stimulate discourse and innovations benefitting patients.METHODSA structured review and expert analysis of PubMed publications before October 2023, with a focus on recent literature from January 2020 through October 2023.RESULTS AND CONCLUSIONGrowing literature supports the utility and benefits of PRP and related autologous products for applications for skin and hair, with strongest evidence for androgenetic alopecia and skin rejuvenation. However, this is limited by lack of consensus regarding best practices and protocols. Randomized, controlled trials with uniform metrics comparing outcomes of various compositions of autologous blood products, preparation methods, dosimetry, and frequency of treatments are still required. This will allow the medical discourse to grow beyond the realm of expert opinion into consensus, standardization, and more wide spread adoption of best practices that will benefit patients.
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U2 - 10.1097/dss.0000000000004115
DO - 10.1097/dss.0000000000004115
M3 - Review article
C2 - 38376068
AN - SCOPUS:85191610017
SN - 1076-0512
VL - 50
SP - 446
EP - 452
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 5
ER -